We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
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0
Vitamin B12 ineffective for CFS
N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports.
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.
In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.
These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
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8
Folic acid boosts cognitive function
Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies.
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.
In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.
After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
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Most Useful Reviews
7.5
Increased energy levels
2 people found this helpful
Perfectly! These small beige tablets are tasteless and odourless. I was prescribed them for anaemia, and after a month of taking one tablet daily, alongside chelated iron and B12, my haemoglobin increased, and my fatigue, pallor, and weakness decreased. Although it takes 2-3 months for complete recovery, I'm confident this really works!
Read More
9
Boosted energy
Folic acid is of excellent quality; the small tablet is easy to swallow with a neutral taste. The large packaging offers a good dosage. I take one tablet daily, and the results are evident. This supplement accelerates metabolism, strengthens the nervous system, and banishes fatigue. I recommend it.
Read More
9
Energy surge
There is no need to expound on the benefits of folic acid! It plays a role in all bodily processes. This brand provides the most effective folic acid; I noticed results within days on my well-being, my skin improved, and nervousness decreased. I feel calmer with an increase in energy. The tablets are small and the taste is neutral. I am pleased.
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.
Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.
Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
Read More
8
Folinic acid may aid CFS
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
Read More
8
Folic acid boosts cognitive function
Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies.
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.
In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.
After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
Read More
8
Vitamin B12 drops show promise
Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders.
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.
After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.
On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
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8
Potential effects on chronic fatigue
Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems.
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.
While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.
Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.
Perfectly! These small beige tablets are tasteless and odourless. I was prescribed them for anaemia, and after a month of taking one tablet daily, alongside chelated iron and B12, my haemoglobin increased, and my fatigue, pallor, and weakness decreased. Although it takes 2-3 months for complete recovery, I'm confident this really works!
Read More
9
Boosted energy
Folic acid is of excellent quality; the small tablet is easy to swallow with a neutral taste. The large packaging offers a good dosage. I take one tablet daily, and the results are evident. This supplement accelerates metabolism, strengthens the nervous system, and banishes fatigue. I recommend it.
Read More
9
Energy surge
There is no need to expound on the benefits of folic acid! It plays a role in all bodily processes. This brand provides the most effective folic acid; I noticed results within days on my well-being, my skin improved, and nervousness decreased. I feel calmer with an increase in energy. The tablets are small and the taste is neutral. I am pleased.
Read More
7.5
Enhanced calmness
10 people found this helpful
There's no need to elaborate on the benefits of folic acid! It plays a role in all bodily processes. This brand provides effective folic acid. After just a few days, I've noticed a significant improvement in my well-being and skin. My nervousness has decreased, and I feel energised, with diminished fatigue. The tablets are small, tasteless, and I am very satisfied with the results.
Read More
6
Effective for fatigue
4 people found this helpful
I really like this brand. The supplements are always of high quality at fair prices. Folic acid helps me manage my fatigue effectively. I highly recommend it!
Chronic Fatigue Syndrome (CFS), also known as Myalgic Encephalomyelitis (ME), is a complex and debilitating condition characterized by profound fatigue that doesn’t improve with rest and worsens with physical or mental activity. This crippling fatigue is often accompanied by a variety of symptoms, including sleep disturbances, cognitive difficulties, muscle pain, and joint pain. Unlike typical tiredness, the fatigue experienced in CFS is long-lasting, and it can significantly hinder everyday activities and overall quality of life.
The precise cause of CFS remains unknown, but it is believed to be influenced by a combination of genetic, environmental, immunological, and psychological factors. Diagnosis primarily relies on a careful assessment of symptoms, as there are no definitive laboratory tests available. Treatment options focus on symptom management and may include lifestyle changes, physical therapy, medication for pain management, and cognitive behavioral therapy. Given the complexity and variability of the condition, individuals with CFS should consult healthcare professionals who specialize in this area to develop personalized management strategies.
Folic acid, also known as vitamin B9, is a water-soluble vitamin that plays a crucial role in many bodily functions, particularly in the synthesis of DNA and RNA. It is essential for cell division and is especially important during periods of rapid growth, such as during pregnancy and infancy. The body cannot produce folic acid on its own, which is why it must be obtained from dietary sources or supplements. Commonly found in leafy green vegetables, legumes, seeds, and fortified foods, folic acid is vital for preventing neural tube defects in developing fetuses and is often recommended for women of childbearing age.
In addition to its key role in pregnancy, folic acid contributes to the production of red blood cells and can help reduce the risk of certain types of anemia. Research has also suggested that adequate folic acid levels may be associated with lowered risk of heart disease and other health issues. Most health organizations recommend a daily intake of 400 micrograms for adults, with higher amounts suggested for pregnant women. Incorporating folate-rich foods into your diet, or considering supplementation, can help ensure you meet your folic acid needs.
Based on user reviews, it appears that individuals report varying times for seeing noticeable results from taking folic acid for Chronic Fatigue Syndrome. Several users mention feeling improvements in their well-being within just a few days of starting the supplement, particularly regarding energy levels and decreased nervousness (Read Review; Read Review). Others, however, indicate that while they felt initial benefits quickly, achieving complete recovery or optimal effects might take longer, with one user noting a timeframe of 2-3 months for full recovery (Read Review).
Overall, many users seem to experience some level of benefit within the first week, making folic acid a potentially effective supplement for reducing fatigue associated with Chronic Fatigue Syndrome. However, for some, it may take consistent usage over several weeks or months to reach their desired level of improvement. As with any supplement, individual responses may vary, so it's advisable to give it time and monitor your own body’s reactions.
The research surrounding supplements like folic acid and vitamin B12 for chronic fatigue syndrome (CFS) presents a mixed picture. For instance, a study assessed the impacts of folic acid combined with B12, where "Good responders" to treatment showed improvements in symptoms based on higher doses and adequate intake of these supplements. However, the variability among patient's responses indicates that while some may benefit, individual treatment plans should be tailored further [1]. Another investigation noted that folinic acid led to symptom improvement in 81% of CFS patients, particularly those with immune deficiencies [2]. This suggests promise, encouraging further exploration into folate as a potential treatment avenue for CFS.
Conversely, some studies have shown inconclusive results regarding vitamin B12's effectiveness alone, with reports indicating no significant benefits when other treatments were in play [8]. It becomes evident that while there are hints of potential benefits from both folate and vitamin B12, the need for more rigorous, focused studies is crucial to better understand their roles in managing CFS. So, if you're considering these supplements, make sure to discuss them with your healthcare provider to ensure their suitability for your unique situation.
Many users have reported noticeable improvements in their symptoms after taking folic acid. A frequent observation is a marked reduction in fatigue, with several individuals feeling more energized and less tired soon after starting the supplement. For instance, one user mentioned a significant boost in their energy levels and a decrease in nervousness within just a few days of use (Read Review; Read Review). Another shared that their feelings of nervousness had diminished alongside increased vitality (Read Review), reinforcing the anecdotal evidence that users tend to feel more balanced and optimistic shortly after starting supplementation.
In addition to energy boosts, several users have noted improvements in their overall well-being, including enhanced skin condition and metabolic processes. One reviewer commented on their improved skin and diminished fatigue as they continued taking folic acid (Read Review). While many experienced these improvements relatively quickly, some users did mention that achieving total recovery or optimal benefits might take a few months (Read Review). Overall, while individual results can vary, the testimonials suggest that folic acid can play a significant role in alleviating fatigue and enhancing overall vitality.
Users report positive experiences when combining folic acid with other supplements to manage Chronic Fatigue Syndrome. Many individuals have taken folic acid alongside minerals such as chelated iron and vitamins like B12. One user noted that after a month of this combination, they saw significant improvements in their fatigue and overall strength, with their haemoglobin levels increasing as well (Read Review). Another review mentioned that folic acid, when taken alongside other vitamins, helped accelerate metabolism and banish fatigue, indicating that it could effectively enhance the results of a broader supplementation regimen (Read Review).
Moreover, users attribute their improved well-being and reduced nervousness to the benefits of folic acid, especially when integrated into their daily routine. The combination of folic acid with other beneficial supplements also seems to lead to increased energy and vitality, as observed by several reviewers who experienced noticeable enhancements in their conditions after starting on a holistic approach to supplementation (Read Review; Read Review). Overall, these testimonials suggest that users feel more empowered in managing their symptoms through strategic combinations of supplements.
Based on user reviews, it appears that a daily dosage of one tablet of folic acid is commonly recommended for treating symptoms of Chronic Fatigue Syndrome. Many users reported positive outcomes after consistently taking one tablet, highlighting increases in energy and reductions in fatigue as notable benefits (review id='99b4a82d-1c0d-48cc-aa1f-c3d4f6e145d5', review id='fac3aad3-003b-47b0-95b8-17018b93e217'). Reviews indicated that users experienced noticeable improvements in their overall well-being, skin condition, and nervousness within a few days to a month of starting supplementation (review id='4f53ed2a-3336-4596-8cd1-055c7b6024a9', review id='547941df-9396-4756-b34d-a6c7a68d1db5').
While specific milligram dosages were not frequently mentioned in the reviews, users did relate their experiences of effective fatigue management to taking this supplement routinely. For instance, one reviewer appreciated the product for its ability to banish fatigue and strengthen the nervous system Read Review, suggesting that consistency and adherence to a daily routine might be more vital than the precise dosage. Thus, it can be inferred that a daily tablet, as part of a comprehensive regimen, may aid individuals managing Chronic Fatigue Syndrome.
9
Energy surge
There is no need to expound on the benefits of folic acid! It plays a role in all bodily processes. This brand provides the most effective folic acid; I noticed results within days on my well-being, my skin improved, and nervousness decreased. I feel calmer with an increase in energy. The tablets are small and the taste is neutral. I am pleased.
7.5
Enhanced calmness
10 people found this helpful
There's no need to elaborate on the benefits of folic acid! It plays a role in all bodily processes. This brand provides effective folic acid. After just a few days, I've noticed a significant improvement in my well-being and skin. My nervousness has decreased, and I feel energised, with diminished fatigue. The tablets are small, tasteless, and I am very satisfied with the results.
7.5
Increased energy levels
2 people found this helpful
Perfectly! These small beige tablets are tasteless and odourless. I was prescribed them for anaemia, and after a month of taking one tablet daily, alongside chelated iron and B12, my haemoglobin increased, and my fatigue, pallor, and weakness decreased. Although it takes 2-3 months for complete recovery, I'm confident this really works!
7.5
Feeling revitalised
I feel noticeably better. Nervousness has reduced, and I have more energy with decreased fatigue.
9
Boosted energy
Folic acid is of excellent quality; the small tablet is easy to swallow with a neutral taste. The large packaging offers a good dosage. I take one tablet daily, and the results are evident. This supplement accelerates metabolism, strengthens the nervous system, and banishes fatigue. I recommend it.
8
Folic acid and B12 show variable benefits
Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia.
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.
Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.
Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
8
Folinic acid may aid CFS
Clinical activity of folinic acid in patients with chronic fatigue syndrome.
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.
Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.
While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.
References
Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648
Lundell K, Qazi S, Eddy L, Uckun FM. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399.
Botez MI, Fontaine F, Botez T, Bachevalier J. Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies. Eur Neurol. 1977;16:230.
Jacobson W, Saich T, Borysiewicz LK, Behan WM, Behan PO, et al. Serum folate and chronic fatigue syndrome. Neurology. 1993;43:2645.
Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989;149:2501.
van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. doi:10.3389/fphar.2019.01102
Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594.
Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301.
Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.