Overview

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
USERS' SCORE
Good
Based on 10 Reviews
8
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
1,360 mcg DFE** (800 mcg folic acid)
340%
Vitamin B-12 (as Cyanocobalamin)
25 mcg
1042%

Top Medical Research Studies

8
Folinic acid may aid CFS
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
0
Vitamin B12 ineffective for CFS
We explored the effectiveness of high-dose vitamin B12 injections on chronic fatigue syndrome (CFS) through two case reports that utilized N of 1 trials. This approach allowed us to make tailored treatment decisions based on individual responses to the therapy.

In one case, we found that high-dose vitamin B12 injections did not yield positive results, leaving the patient without significant relief from their symptoms. Conversely, in another case, we observed that nimodipine proved to be a very effective treatment for that patient’s chronic fatigue.

These findings suggest that while vitamin B12 may not be helpful for everyone suffering from CFS, other treatments like nimodipine can be beneficial. Thus, personalized treatment strategies are key in managing this complex and varied condition.
8
Folic acid boosts cognitive function
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.

In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.

After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.

Most Useful Reviews

7.5
Increased energy levels
2 people found this helpful
Perfectly! These small beige tablets are tasteless and odourless. I was prescribed them for anaemia, and after a month of taking one tablet daily, alongside chelated iron and B12, my haemoglobin increased, and my fatigue, pallor, and weakness decreased. Although it takes 2-3 months for complete recovery, I'm confident this really works!
9
Boosted energy
Folic acid is of excellent quality; the small tablet is easy to swallow with a neutral taste. The large packaging offers a good dosage. I take one tablet daily, and the results are evident. This supplement accelerates metabolism, strengthens the nervous system, and banishes fatigue. I recommend it.
9
Energy surge
There is no need to expound on the benefits of folic acid! It plays a role in all bodily processes. This brand provides the most effective folic acid; I noticed results within days on my well-being, my skin improved, and nervousness decreased. I feel calmer with an increase in energy. The tablets are small and the taste is neutral. I am pleased.

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6.2
  • All Researches
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.

Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.

Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
8
Folinic acid may aid CFS
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
8
Folic acid boosts cognitive function
We examined the effects of folic acid treatment on patients experiencing chronic fatigue related to neurological and psychiatric disorders.

In a group of 16 patients—some with known folate deficiency and others with idiopathic cases—we found common complaints of exhaustion and cognitive issues.

After 6 to 12 months of folic acid therapy, we noted significant improvements in intellectual functioning through various tests. This suggests that addressing folate deficiencies may help alleviate some symptoms of chronic fatigue.
8
Vitamin B12 drops show promise
We examined the impact of vitamin B12 nasal drops on individuals suffering from myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Our study involved fifty-one patients, predominantly female, with an average age of 42 and an average illness duration of 16 years.

After three months of treatment, we measured their vitamin B12 serum levels, physical activity, and fatigue and concentration levels. Interestingly, we found that the participants who responded positively to the treatment experienced significant improvements in their vitamin B12 levels, daily step count, and overall physical activity. Moreover, those who reported a positive response noted a decrease in fatigue levels.

On the flip side, those categorized as non-responders had only a modest increase in vitamin B12 levels, with no notable improvement in other measures. Overall, our findings suggest that nasal drops could serve as a viable alternative to vitamin B12 injections, especially since around two-thirds of participants reported feeling better after treatment. This pilot study opens up new avenues for interventions in managing ME/CFS and highlights the importance of considering alternative treatment methods.
8
Potential effects on chronic fatigue
We recently came across an intriguing study that highlighted the potential benefits of a combination therapy involving lofepramine, L-phenylalanine, and vitamin B12 for patients suffering from multiple sclerosis (MS). Conducted as a randomized, placebo-controlled double-blind trial, the research aimed to evaluate how this combination could help alleviate various symptoms associated with MS and chronic pain.

While this study did address the role of vitamin B12, it was examined alongside lofepramine and phenylalanine. This makes it challenging for us to pinpoint the specific impact of vitamin B12 in the context of chronic fatigue syndrome on its own. The treatment showed effectiveness in improving symptoms within just two to four weeks, but due to the combination of treatments, we need more focused studies to assess vitamin B12's distinct role.

Overall, it's exciting to see a potential link between this therapy and symptom relief, yet we must remain cautious about attributing the benefits solely to vitamin B12, given the blended approach of the therapy used in the trial.

User Reviews

USERS' SCORE
Good
Based on 10 Reviews
8
  • All Reviews
  • Positive Reviews
  • Negative Reviews
7.5
Increased energy levels
2 people found this helpful
Perfectly! These small beige tablets are tasteless and odourless. I was prescribed them for anaemia, and after a month of taking one tablet daily, alongside chelated iron and B12, my haemoglobin increased, and my fatigue, pallor, and weakness decreased. Although it takes 2-3 months for complete recovery, I'm confident this really works!
9
Boosted energy
Folic acid is of excellent quality; the small tablet is easy to swallow with a neutral taste. The large packaging offers a good dosage. I take one tablet daily, and the results are evident. This supplement accelerates metabolism, strengthens the nervous system, and banishes fatigue. I recommend it.
9
Energy surge
There is no need to expound on the benefits of folic acid! It plays a role in all bodily processes. This brand provides the most effective folic acid; I noticed results within days on my well-being, my skin improved, and nervousness decreased. I feel calmer with an increase in energy. The tablets are small and the taste is neutral. I am pleased.
7.5
Enhanced calmness
10 people found this helpful
There's no need to elaborate on the benefits of folic acid! It plays a role in all bodily processes. This brand provides effective folic acid. After just a few days, I've noticed a significant improvement in my well-being and skin. My nervousness has decreased, and I feel energised, with diminished fatigue. The tablets are small, tasteless, and I am very satisfied with the results.
6
Effective for fatigue
4 people found this helpful
I really like this brand. The supplements are always of high quality at fair prices. Folic acid helps me manage my fatigue effectively. I highly recommend it!

Frequently Asked Questions

9
Energy surge
There is no need to expound on the benefits of folic acid! It plays a role in all bodily processes. This brand provides the most effective folic acid; I noticed results within days on my well-being, my skin improved, and nervousness decreased. I feel calmer with an increase in energy. The tablets are small and the taste is neutral. I am pleased.
7.5
Enhanced calmness
10 people found this helpful
There's no need to elaborate on the benefits of folic acid! It plays a role in all bodily processes. This brand provides effective folic acid. After just a few days, I've noticed a significant improvement in my well-being and skin. My nervousness has decreased, and I feel energised, with diminished fatigue. The tablets are small, tasteless, and I am very satisfied with the results.
7.5
Increased energy levels
2 people found this helpful
Perfectly! These small beige tablets are tasteless and odourless. I was prescribed them for anaemia, and after a month of taking one tablet daily, alongside chelated iron and B12, my haemoglobin increased, and my fatigue, pallor, and weakness decreased. Although it takes 2-3 months for complete recovery, I'm confident this really works!
7.5
Feeling revitalised
I feel noticeably better. Nervousness has reduced, and I have more energy with decreased fatigue.
9
Boosted energy
Folic acid is of excellent quality; the small tablet is easy to swallow with a neutral taste. The large packaging offers a good dosage. I take one tablet daily, and the results are evident. This supplement accelerates metabolism, strengthens the nervous system, and banishes fatigue. I recommend it.
We assessed how folic acid, combined with vitamin B12, affects patients with chronic fatigue syndrome, or myalgic encephalomyelitis (ME). In this study, 38 patients were surveyed after receiving weekly B12 injections for six months to several years.

Those classified as "Good responders" showed significant improvements compared to "Mild responders." They had higher doses of B12, more oral folic acid intake, and less reliance on strong painkillers.

Overall, while some experienced meaningful benefits, the variability among responses suggests further research is needed to tailor treatments effectively.
8
Folinic acid may aid CFS
We investigated the effects of folinic acid on patients with chronic fatigue syndrome (CFS), where many also showed signs of B-cell immunodeficiency and reactivated Epstein-Barr virus (EBV) infection. Among 58 evaluated patients, a significant 81% reported symptom improvement after folinic acid treatment. This suggests that many CFS cases may respond positively to folinic acid, shedding light on a possible therapeutic avenue.
7
Vitamin B12 shows unclear benefits
We explored the effect of vitamin B12 on individuals diagnosed with chronic fatigue syndrome. The study focused on assessing how this vitamin might alleviate the symptoms associated with the condition. While many participants underwent concurrent treatments, which complicates isolating vitamin B12's specific impact, the research still provides insightful data.

Participants were monitored to see if vitamin B12 made a notable difference in fatigue levels and overall well-being. However, it appeared that the results were not overwhelmingly positive. The concurrent treatments among participants diluted our ability to assess the true effectiveness of vitamin B12 on its own, leading to an inconclusive outcome.

While we acknowledge the interest in vitamin B12 as a potential remedy for chronic fatigue syndrome, the findings suggest no significant benefits can be attributed to it directly. More focused research might be necessary to fully understand how—or if—vitamin B12 can support those dealing with this challenging syndrome.

References

  1. Regland B, Forsmark S, Halaouate L, Matousek M, Peilot B, et al. Response to vitamin B12 and folic acid in myalgic encephalomyelitis and fibromyalgia. PLoS One. 2015;10:e0124648. doi:10.1371/journal.pone.0124648
  2. Lundell K, Qazi S, Eddy L, Uckun FM. Clinical activity of folinic acid in patients with chronic fatigue syndrome. Arzneimittelforschung. 2006;56:399.
  3. Botez MI, Fontaine F, Botez T, Bachevalier J. Folate-responsive neurological and mental disorders: report of 16 cases. Neuropsychological correlates of computerized transaxial tomography and radionuclide cisternography in folic acid deficiencies. Eur Neurol. 1977;16:230.
  4. Jacobson W, Saich T, Borysiewicz LK, Behan WM, Behan PO, et al. Serum folate and chronic fatigue syndrome. Neurology. 1993;43:2645.
  5. Kaslow JE, Rucker L, Onishi R. Liver extract-folic acid-cyanocobalamin vs placebo for chronic fatigue syndrome. Arch Intern Med. 1989;149:2501.
  6. van Campen CLM, Riepma K, Visser FC. Open Trial of Vitamin B12 Nasal Drops in Adults With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Comparison of Responders and Non-Responders. Front Pharmacol. 2019;10:1102. doi:10.3389/fphar.2019.01102
  7. Loder C, Allawi J, Horrobin DF. Treatment of multiple sclerosis with lofepramine, L-phenylalanine and vitamin B(12): mechanism of action and clinical importance: roles of the locus coeruleus and central noradrenergic systems. Med Hypotheses. 2002;59:594.
  8. Devitt NF. Chronic fatigue syndrome. JAMA. 1998;279:432.
  9. Regland B, Andersson M, Abrahamsson L, Bagby J, Dyrehag LE, et al. Increased concentrations of homocysteine in the cerebrospinal fluid in patients with fibromyalgia and chronic fatigue syndrome. Scand J Rheumatol. 1997;26:301.
  10. Wiebe E. N of 1 trials. Managing patients with chronic fatigue syndrome: two case reports. Can Fam Physician. 1996;42:2214.
  11. Demitrack MA, Engleberg NC. Chronic fatigue syndrome. Curr Ther Endocrinol Metab. 1994;5:135.
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